Unit convenor and teaching staff |
Unit convenor and teaching staff
Bhumika Shah
Bridget Mabbutt
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Credit points |
Credit points
4
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Prerequisites |
Prerequisites
Admission to MRes
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Corequisites |
Corequisites
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Co-badged status |
Co-badged status
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Unit description |
Unit description
This unit outlines molecular principles underlying today's developments in protein science and biomedical research. As well as detailing modern separation technologies, the course addresses structural biology, protein analysis and bioinformatics. Practices common in the biotechnology and pharmaceutical industries to isolate recombinant proteins are emphasized. Analysis methods are introduced in relation to proteomics, genomics and biochemical research. Molecular properties leading to the 3D shape of proteins are detailed and contemporary structure methods outlined.
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Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates
On successful completion of this unit, you will be able to:
Name | Weighting | Due |
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Final examination | 40% | University Examination period |
Laboratory reports | 25% | May 6, May 26 |
“Pet Protein” case project | 25% | April 11, June 2 or June 9 |
Class quizzes | 10% | periodic |
Due: University Examination period
Weighting: 40%
This written exam is based on problem-solving exercises.
Due: May 6, May 26
Weighting: 25%
Due: April 11, June 2 or June 9
Weighting: 25%
Due: periodic
Weighting: 10%
Your Classes
Laboratory Sessions
Required and Recommended texts
The textbook of which you are expected to purchase a personal copy is: “Physical Biochemistry: Principles and Applications”, David Sheehan, John Wiley (2nd ed, 2002).
Because of the multidisciplinary nature of this course, you will be expected to read more widely than this, however. The library has an excellent collection of up-to-date reference material to cover the course and laboratory subjects - explore it!!
Web resources
The Unit will run as an online unit within iLearn (http://learn.mq.edu.au). Within this Unit, you will be introduced to Web-based tools, search engines and graphics software that are commonly used today in protein science. There are many excellent websites, apps and YouTube presentations to show how protein are made and constantly move around.
It is an expectation that you will become familiar with the following sites during the course:
This is a centralised resource for “vital statistics” of known proteins. Try out your Pet Protein here!
“Proteomics” website hosted by the Swiss Intitute for Bioinformatics. Provides many of the tools for doing your own protein analysis & bioinformatics. Good links, so start here.
Essential for your literature searches-free and easy searching of all journals- anywhere, anytime.
the world’s central protein structure database. Use this to locate structures and view them in 3D.
Technology Requirements
Within this Unit, you will be introduced to Web-based tools, search engines and graphics software that are commonly used today in biomedical science. You will require internet access and a computer for web browsing, preparation of your reports and case study analysis. Your project and laboratory reports will be submitted and circulated via the online Turnitin program.
Your practical reports will require you to carry out minor computational tasks, for which a calculator and access to basic statistical software will be required. We place a large emphasis on correct referencing style in all your reports, and use of the program EndNote is encouraged, but not essential.
The capacity to download and install a simple molecular graphics program will assist you greatly in the Unit. Your model-building assessment task can be carried out with very simple materials; it is not an expectation that expensive art supplies need be purchased.
Lectures
1 - 3 FUNCTIONAL GROUPS IN PROTEINS
4 ISOLATING BIOMOLECULES
5 & 6 SEPARATION OF PROTEINS
7 & 8 PROTEIN ANALYSIS
9 FLUORESCENCE TECHNOLOGIES (LB)
10 - 13 CHROMATOGRAPHY FOR PURIFICATION
14 PROTEIN ANALYSIS (cont.)
15 - 17 PROTEIN FOLDS AND DOMAINS
18 - 20 TERTIARY STRUCTURE DETERMINATION
21 & 22 HOW PROTEINS FOLD IN SOLUTION
23 & 24 BIOINFORMATICS
25 MEMBRANE PROTEINS
Macquarie University policies and procedures are accessible from Policy Central. Students should be aware of the following policies in particular with regard to Learning and Teaching:
Academic Honesty Policy http://mq.edu.au/policy/docs/academic_honesty/policy.html
New Assessment Policy in effect from Session 2 2016 http://mq.edu.au/policy/docs/assessment/policy_2016.html. For more information visit http://students.mq.edu.au/events/2016/07/19/new_assessment_policy_in_place_from_session_2/
Assessment Policy prior to Session 2 2016 http://mq.edu.au/policy/docs/assessment/policy.html
Grading Policy prior to Session 2 2016 http://mq.edu.au/policy/docs/grading/policy.html
Grade Appeal Policy http://mq.edu.au/policy/docs/gradeappeal/policy.html
Complaint Management Procedure for Students and Members of the Public http://www.mq.edu.au/policy/docs/complaint_management/procedure.html
Disruption to Studies Policy http://www.mq.edu.au/policy/docs/disruption_studies/policy.html The Disruption to Studies Policy is effective from March 3 2014 and replaces the Special Consideration Policy.
In addition, a number of other policies can be found in the Learning and Teaching Category of Policy Central.
Macquarie University students have a responsibility to be familiar with the Student Code of Conduct: https://students.mq.edu.au/support/student_conduct/
Results shown in iLearn, or released directly by your Unit Convenor, are not confirmed as they are subject to final approval by the University. Once approved, final results will be sent to your student email address and will be made available in eStudent. For more information visit ask.mq.edu.au.
Macquarie University provides a range of support services for students. For details, visit http://students.mq.edu.au/support/
Learning Skills (mq.edu.au/learningskills) provides academic writing resources and study strategies to improve your marks and take control of your study.
Students with a disability are encouraged to contact the Disability Service who can provide appropriate help with any issues that arise during their studies.
For all student enquiries, visit Student Connect at ask.mq.edu.au
For help with University computer systems and technology, visit http://www.mq.edu.au/about_us/offices_and_units/information_technology/help/.
When using the University's IT, you must adhere to the Acceptable Use of IT Resources Policy. The policy applies to all who connect to the MQ network including students.
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