Unit convenor and teaching staff |
Unit convenor and teaching staff
Unit Convenor
Joanne Jamie
Contact via joanne.jamie@mq.edu.au
F7B231
Students are encouraged to arrange a meeting via email.
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Credit points |
Credit points
3
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Prerequisites |
Prerequisites
CBMS204 and (3cp from CBMS200-CBMS203 or CBMS205-CBMS234)
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Corequisites |
Corequisites
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Co-badged status |
Co-badged status
This unit is co-badged with CBMS706 and CBMS842 Medicinal Chemistry
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Unit description |
Unit description
Medicinal chemistry is the application of chemistry to the discovery, design and synthesis of new drugs. This unit is of value to all chemistry, biomolecular sciences and medical sciences students. The central core of the unit is the description of methods used for the discovery of new drugs, how these are modified to produce more active compounds, transportation to and from their points of action and how they are cleared from the body. Topics include: the structure and function of biological targets (proteins and DNA); sources of new drugs from nature; and lead generation and methods of lead modification to make more active, selective or less toxic drugs. This is followed by a study of structure – activity relationship methods; pharmacokinetics, drug metabolism and prodrugs, and chemical genetics. Case studies are also provided, including antibacterial and anticancer agents, and nucleic acid therapies. The theory is complemented by a discovery-based laboratory project incorporating synthetic chemistry, spectroscopic methods, bioassays and computational chemistry to elucidate the essential structural features necessary for the sulfonamide class of antibacterial agents.
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Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates
On successful completion of this unit, you will be able to:
Name | Weighting | Due |
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Practical Reports | 25% | March 14, April 11, June 16 |
Mid-semester test | 10% | May 16, 1pm |
Spot tests | 5% | any stage in lectures |
Assignment | 10% | April 28, 9am, Student Centre |
Final exam | 50% | TBA |
Due: March 14, April 11, June 16
Weighting: 25%
The practical work (synthesis and antibacterial structure activity relationship of sulfonamides) will be conducted in groups, with ~4-6 people per group. For each group a report in the style of a journal article will be produced at the end of the semester. Following your week 1 laboratory preparation session (March 7), in week 2 in the Friday March 14 lecture/tutorial class, each group will be asked to present a short oral presentation on the justification of your group’s choice of final target compounds and possible synthetic procedures. In week 6 (April 11), each of you will submit your laboratory notebook and each group will present a formal write up of the experimental procedure for the synthesis of one of your sulfonyl chloride-amine condensation products, including spectral data by the end of the laboratory session. Feedback will be provided to help you improve your scientific writing skills and laboratory practices and for general understanding of the practical work. The combined week 2 and week 6 assessment tasks will be worth 7.5% (5% individual mark, 2.5% group mark). At the end of the semester (by Week 14, Monday June 16, 5pm to Prof Karuso, F7B232), each group will hand in the final report written in journal format and each student will hand in their laboratory notebook. The whole group will get the same mark for the report (/10%), but each student will be given an individual mark for their laboratory notebook, general safety and participation in the laboratory (/7.5%). Proper recording of experimental procedures and spectral data, analysis of results and discussion and conclusion of these will all be taken into account in the marking. Full details on what is expected for assessment of the practical component is provided in the laboratory manual and on the web site (see under “Laboratory Notes”).
Due: May 16, 1pm
Weighting: 10%
There will be a 50 minute test (/10%) in Week 9, Friday May 16, 1 pm sharp. This will cover up to the end of prodrugs. This is designed to give you specific feedback on your understanding of the topics up to this stage to assist you in your further study of the unit.
Due: any stage in lectures
Weighting: 5%
Spot tests (/5%) may be conducted at any stage within the lectures. They are to encourage continuous learning of the lecture material without the stress of a significant assessment component.
Due: April 28, 9am, Student Centre
Weighting: 10%
The assignment consists of a report (10%) that summarises the chemical and biological properties of a pharmaceutical agent in current use and how these relate to its function and properties in the body, along with general historical importance of the drug. This assignment is designed to provide skills in searching the literature and understanding the properties of the pharmaceutical agent from a molecular point of view. The assignment is due Week 7, Tuesday, April 28, 9am, Science Student Centre, E7A. It must be accompanied with the assignment cover sheet provided on the web site.
Due: TBA
Weighting: 50%
The final exam (/50%) will be 3 hours in length with 10 minutes reading time. It is designed to assess specific understanding and holistic concepts of all the topics presented within the course and an opportunity for you to show what knowledge you have obtained and how you can be apply this to new problems.
The web page for this unit can be found at ilearn.mq.edu.au.
Just login and follow the prompts to CBMS306 Medicinal Chemistry.
You can use any web browser such as Firefox, Internet Explorer or Safari to login.
iLearn is the name for Macquarie University’s new Learning Management System (LMS). The iLearn online learning environment enables learning, teaching, communication and collaboration. It is used to make lecture notes, laboratory notes, discussion forums, digital lecture recordings and other learning resources available to students online.
CBMS306 is a 3 credit point unit and will require an average of 9 hours of work (contact and self study time) per week. For students with weak chemistry backgrounds, more time than the average 9 hours per week will probably be necessary to perform satisfactorily in this unit. CBMS306 is run with three hours of lectures/tutorials per week, along with 4 hour blocks of laboratories/workshops. Students are required to attend all lectures, tutorials and laboratory classes. Active participation by the students in all of these fora is expected.
Further information on technology used: You are expected to access the unit web site frequently This contains important information including notes on the topics to be covered; the laboratory manual; What You Need to Know Sheets; your marks for practicals, quizzes and the mid-session exam; and past exam papers, including with answers. Additionally, the web site will also be used to post important messages and links to internet facilities and sites of relevance to the course, downloadable software, and lots of other interesting material.
If you do not have your own computer you may wish to access the Medicinal Chemistry web resources on campus using the PC computers in the Library or in the C5C computer laboratories. To view notes on all the topics and past exams on the unit web site, you will require Adobe Acrobat Reader Version 9 or later to be installed on your computer. Acrobat Reader can be downloaded from the Adobe web site http://get.adobe.com/uk/reader/. If you are using the computers in the library, then Acrobat has already been installed. Please note information will also be sent by email to your student email account so please look at your email account on a frequent basis.
You are expected to access SciFinder Scholar and Reaxys to assist in searching the literature. These are available through the library web site.
Hand-held calculators will be occasionally used in tutorials and practicals, for tests and in the final examination. Note that text-retrieval calculators are not allowed in the in-semester tests or final examination.
Changes from previously: The unit is being run similarly to 2013, with minor changes.
The first 3/4 of CBMS306 will provide an overview of the important concepts in medicinal chemistry and the last 1/4 will concentrate on case studies. CBMS306 has three hours/week allocated to lectures/tutorials. While formal lectures will be presented, discussion sessions will also form a major part of the classes. This will be supplemented by practical classes utilising synthetic chemistry, spectroscopic methods and bioassays.
The laboratory classes will be run in groups and students are required to, in part, design the experiments, using literature procedures as a guide. Considerable preparation is therefore needed. Past students have found this a valuable experience as it gives them a realistic approach to conducting research. The laboratory classes will run every week, Friday 2-6 pm except the mid-session break and weeks 12 and 13.
In week 1, the laboratory class will be a preparative session, in which the groups will discuss structure-activity relationships and use this to rationally choose their target sulfonamides, learn how to use SciFinder Scholar and Reaxys for literature searching and start to identify key preparative methods for the sulfonamides, and prepare flow diagram and risk assessment forms for commencement of the wet laboratory classes (beginning week 2).
This week 1 preparative session will be run in the write-up room E7B346, and commence at 2pm. The laboratory classes will run from week 2 in laboratory E7B350. The 2-6pm session of weeks 12 and 13 will be used for finalising the laboratory report and the write-up room will be available for this.
Macquarie University policies and procedures are accessible from Policy Central. Students should be aware of the following policies in particular with regard to Learning and Teaching:
Academic Honesty Policy http://mq.edu.au/policy/docs/academic_honesty/policy.html
Assessment Policy http://mq.edu.au/policy/docs/assessment/policy.html
Grading Policy http://mq.edu.au/policy/docs/grading/policy.html
Grade Appeal Policy http://mq.edu.au/policy/docs/gradeappeal/policy.html
Grievance Management Policy http://mq.edu.au/policy/docs/grievance_management/policy.html
Disruption to Studies Policy http://www.mq.edu.au/policy/docs/disruption_studies/policy.html The Disruption to Studies Policy is effective from March 3 2014 and replaces the Special Consideration Policy.
In addition, a number of other policies can be found in the Learning and Teaching Category of Policy Central.
Macquarie University students have a responsibility to be familiar with the Student Code of Conduct: https://students.mq.edu.au/support/student_conduct/
Macquarie University provides a range of support services for students. For details, visit http://students.mq.edu.au/support/
Learning Skills (mq.edu.au/learningskills) provides academic writing resources and study strategies to improve your marks and take control of your study.
Students with a disability are encouraged to contact the Disability Service who can provide appropriate help with any issues that arise during their studies.
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We want our graduates to have emotional intelligence and sound interpersonal skills and to demonstrate discernment and common sense in their professional and personal judgement. They will exercise initiative as needed. They will be capable of risk assessment, and be able to handle ambiguity and complexity, enabling them to be adaptable in diverse and changing environments.
This graduate capability is supported by:
Our graduates will have enquiring minds and a literate curiosity which will lead them to pursue knowledge for its own sake. They will continue to pursue learning in their careers and as they participate in the world. They will be capable of reflecting on their experiences and relationships with others and the environment, learning from them, and growing - personally, professionally and socially.
This graduate capability is supported by:
Our graduates will take with them the intellectual development, depth and breadth of knowledge, scholarly understanding, and specific subject content in their chosen fields to make them competent and confident in their subject or profession. They will be able to demonstrate, where relevant, professional technical competence and meet professional standards. They will be able to articulate the structure of knowledge of their discipline, be able to adapt discipline-specific knowledge to novel situations, and be able to contribute from their discipline to inter-disciplinary solutions to problems.
This graduate capability is supported by:
We want our graduates to be capable of reasoning, questioning and analysing, and to integrate and synthesise learning and knowledge from a range of sources and environments; to be able to critique constraints, assumptions and limitations; to be able to think independently and systemically in relation to scholarly activity, in the workplace, and in the world. We want them to have a level of scientific and information technology literacy.
This graduate capability is supported by:
Our graduates should be capable of researching; of analysing, and interpreting and assessing data and information in various forms; of drawing connections across fields of knowledge; and they should be able to relate their knowledge to complex situations at work or in the world, in order to diagnose and solve problems. We want them to have the confidence to take the initiative in doing so, within an awareness of their own limitations.
This graduate capability is supported by:
Our graduates will also be capable of creative thinking and of creating knowledge. They will be imaginative and open to experience and capable of innovation at work and in the community. We want them to be engaged in applying their critical, creative thinking.
This graduate capability is supported by:
We want to develop in our students the ability to communicate and convey their views in forms effective with different audiences. We want our graduates to take with them the capability to read, listen, question, gather and evaluate information resources in a variety of formats, assess, write clearly, speak effectively, and to use visual communication and communication technologies as appropriate.
This graduate capability is supported by:
As local citizens our graduates will be aware of indigenous perspectives and of the nation's historical context. They will be engaged with the challenges of contemporary society and with knowledge and ideas. We want our graduates to have respect for diversity, to be open-minded, sensitive to others and inclusive, and to be open to other cultures and perspectives: they should have a level of cultural literacy. Our graduates should be aware of disadvantage and social justice, and be willing to participate to help create a wiser and better society.
This graduate capability is supported by:
We want our graduates to be aware of and have respect for self and others; to be able to work with others as a leader and a team player; to have a sense of connectedness with others and country; and to have a sense of mutual obligation. Our graduates should be informed and active participants in moving society towards sustainability.
This graduate capability is supported by:
· Lecturer Prof Peter Karuso, F7B232, ph 98508290, peter.karuso@mq.edu.au
· Guest lecturer Prof Shoba Ranganathan, F7B121, ph 98506262, shoba.ranganathan@mq.edu.au
There are no formal office hours for the teaching staff, however, you are expected to contact them on any questions you have with their topics and the unit convenor on any administrative questions as soon as your concern arises. You are encouraged to phone or email to organise a meeting. You may also wish to ask questions using the discussion board on the website.