Coronavirus (COVID-19) Update
Due to the Coronavirus (COVID-19) pandemic, any references to assessment tasks and on-campus delivery may no longer be up-to-date on this page.
Students should consult iLearn for revised unit information.
Find out more about the Coronavirus (COVID-19) and potential impacts on staff and students
Unit convenor and teaching staff |
Unit convenor and teaching staff
Bridget Mabbutt
Alison Rodger
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Credit points |
Credit points
10
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Prerequisites |
Prerequisites
Admission to MRes
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Corequisites |
Corequisites
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Co-badged status |
Co-badged status
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Unit description |
Unit description
This unit outlines molecular principles underlying today's developments in protein science and biomedical research. As well as detailing modern separation technologies, the course addresses structural biology, protein analysis and bioinformatics. Practices common in the biotechnology and pharmaceutical industries to isolate recombinant proteins are emphasized. Analysis methods are introduced in relation to proteomics, genomics and biochemical research. Molecular properties leading to the 3D shape of proteins are detailed and contemporary structure methods outlined.
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Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates
On successful completion of this unit, you will be able to:
Coronavirus (COVID-19) Update
Assessment details are no longer provided here as a result of changes due to the Coronavirus (COVID-19) pandemic.
Students should consult iLearn for revised unit information.
Find out more about the Coronavirus (COVID-19) and potential impacts on staff and students
Due: In scheduled lectures. Weighting: 40%
Four separate quizzes (30 min) will be administered during Thursday lectures throughout semester (weeks 2, 4, 10 and 12). These open-book tests will incorporate problem-solving exercises utilising lecture material covered in preceding weeks.
Due: Apr 3. Weighting: 15%
In the Week 3 workshop, you will be allocated a specific protein of industrial/medical importance as a case-study ("Pet Protein") for the semester.
You will analyse the sequence of your individual Pet Protein using relevant software tools.
You will undertake a literature search to locate primary journal sources for methodological details about (i) the initial historical isolation of this protein, and (ii) its modern recombinant production for industrial or laboratory purpose.
You will provide a chemical analysis of the separation steps of these two procedures, and present in both flow chart and text forms.
The full submission requirements for this report, and its marking rubric will be provided on iLearn.
Due: May 1 Weighting: 15%
Due: May 8 Weighting: 10%
Due: Week 12 or 13, as advised. Weighting: 20%
This is a continuation of the Pet Protein case study. You will transmit your understanding of your Pet Protein to fellow students via presentation (10 min, 10%), and your own constructed three-dimensional protein model (10%) .
Coronavirus (COVID-19) Update
Any references to on-campus delivery below may no longer be relevant due to COVID-19.
Please check here for updated delivery information: https://ask.mq.edu.au/account/pub/display/unit_status
Teaching Staff:
Classes:
Laboratory Sessions:
A Protein Purification Practical is scheduled in the first week of mid-semester break.
All students are required to attend practicals scheduled for two designated days within the week of Apr 14th-17th (Tue - Fri).
You will be allocated a workshop group (group 1, 2, 3 or 4) by the Unit convenor and communicated via the iLearn interface. You are not permitted to change groups during semester. Each of you need to attend for 2 hr sessions.
Required and Recommended texts
Web resources
The Unit will run as an online unit within iLearn (http://learn.mq.edu.au).
Within this course, you will be introduced to search engines and graphics software commonly used in protein science. It is an expectation that you will become familiar with the following sites :
Technology Requirements
preparation of your reports and presentations (Word and PowerPoint software).
• Your project and laboratory reports will be electronically submitted via the online Turnitin program within the iLearn portal.
• Your practical reports will require you to carry out minor arithmetical tasks, for which a calculator and access to basic statistical software will be required.
• We place a strong emphasis on correct referencing style in all your reports. Use of the program EndNote is encouraged.
• Your model-building assessment task can be carried out with very simple materials; it is not an expectation that expensive art supplies need be purchased.
Coronavirus (COVID-19) Update
The unit schedule/topics and any references to on-campus delivery below may no longer be relevant due to COVID-19. Please consult iLearn for latest details, and check here for updated delivery information: https://ask.mq.edu.au/account/pub/display/unit_status
Lecture topics and Practical schedule
1 - 3 |
PROTEIN ENGINEERING |
4 & 5 |
ISOLATING PROTEINS |
6 - 9 |
SEPARATION OF PROTEINS |
10 & 11 |
MASS SPECTROMETRY & GLYCOMICS |
12 - 15 |
PROTEIN FOLDS AND DOMAINS |
16 | MEMBRANE PROTEINS |
17-21 |
TERTIARY STRUCTURE DETERMINATION |
22-24 |
HOW PROTEINS FOLD IN SOLUTION |
25 & 26 |
BIOINFORMATICS |
Teaching week |
Date |
Workshop theme |
Report due |
Student group |
Week 3 |
Mar 11 or 12 |
Searching the primary literature |
4pm Fri Apr 3 |
Mar 11 4-6 pm, group 1 6-8 pm, group 2 Mar 12: 9-11 am, group 3 11-1pm, group 4 |
Mid-semester break |
Apr 14-17 |
Protein production practical |
4pm Fri May 1 |
whole days, 9-4pm Apr 14-15 groups 1&2 Apr 16-17 groups 3&4 |
Week 8 |
Apr 29 or 30
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Molecular graphics |
4pm Fri May 8 |
Apr 29 4-6 pm, group 1 6-8 pm, group 2 Apr 30 9-11 am, group 3 11-1pm, group 4 |
Week 10 |
May 6 or 7 |
At the movies: Crystallography |
May 6 or 7 (in class) |
May 6: 4-6 pm, groups 1&2 Mar 7: 11-1pm, groups 3&4 |
Week 12 |
May 27 or 28 |
Presentations: Pet protein structure |
in class |
May 27: 4-7 pm, group 1 May 28: 10-1 pm, group 3 |
Week 13 |
Jun 3 or 4 |
Presentations: Pet protein structure |
in class |
Jun 3: 4-7 pm, group 2 Jun 4: 10-1pm, group 4 |
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