Wk 1-5 Professor Peter Karuso (Primary and Secondary Metabolism)
The first four-week section will introduce you to the chemistry of biological systems, from primary metabolism and energy production to secondary metabolism. We will dissect mechanisms behind how and why nature has chosen specific pathways to synthesise new molecules and convert one molecule into another.
Wk 1: The Origin of Life, the Universe and well everything...
Wk 2: Reactions in Primary and Secondary Metabolism (Assignment PK1 due)
Wk 3: Bizarre Chemistry of Primary Metabolism (Assignment PK2 due)
Wk4: Alkaloids (Assignment PK3 due)
Wk 4: Fatty acids/Polyketides (Assignment PK4 due)
Wk 6-9 Dr Andrew Piggott (Natural Product Biosynthesis)
This section will build on the groundwork laid in Weeks 1-4 and highlight other important biosynthetic pathways used by Nature to construct specific types of natural products
Wk 5: The shikimate pathway
Wk 6: The mevalonic acid pathway(s) and terpenoids (Assignment AP1 due)
Wk 7: Heteroaromatics; pyrimidines, purine, pteridines, pyrroles & porphyrins (Assignment AP2 due)
Wk 8: Student Presentations (Assignment AP3 due)
Wk 10-13 Dr Fei Liu (Small Molecules in Chemical Biology)
Small molecules are frequently used as chemical tools for probing biological systems or engineering new bio-networks with new function. This section will cover current topics in the use of chemical tools in mammalian systems that have led to new approaches in drug discovery and elucidation of new cellular mechanisms.
Wk 9: Introduction to the uses of small molecules in chemical biology
Wk 10: Probing protein pathways with small molecules (Assignment FL1 due)
Wk 11: Targeted molecular therapeutics (Assignment FL2 due)
Wk 12: Student presentations