Unit convenor and teaching staff |
Unit convenor and teaching staff
Convenor, Lecturer
Ian Paulsen
6 Wally's Walk, Room 311
Lecturer
Paul Haynes
Lab Tech
Thi Huynh
Lab Tech
Angela Moncrieff
Administration
Belinda Fabian
Administration
Iniga George
|
---|---|
Credit points |
Credit points
10
|
Prerequisites |
Prerequisites
130cp at 1000 level or above including BMOL2201 or CBMS201 or CBMS223
|
Corequisites |
Corequisites
|
Co-badged status |
Co-badged status
|
Unit description |
Unit description
Molecular biology is a central science in twenty-first century biology and biotechnology. Understanding the fundamentals of molecular biology is essential for many other fields in the life sciences, including microbiology, cell biology, immunology, and development. Molecular biology makes a significant and increasing contribution to major sectors of our society including agriculture and medicine, and is also important in environmental science and forensics. In this unit we explore topics that allow students to obtain an advanced understanding of the mechanisms of molecular biology, including those of DNA replication and recombination, prokaryotic gene expression, eukaryotic gene expression, mobile elements, the functions of the nucleus, and epigenetics. We also address topics on the rapidly changing technologies in molecular biology, including those used in genome sequencing, metagenomics, systems and synthetic biology. Practical sessions complement the lectures and provide students with hands-on experience with a range of critical laboratory skills including those required for DNA and RNA isolation, PCR and RT-PCR, cloning, and bioinformatics. Students gain experience in working with both bacterial and eukaryotic systems in the laboratory classes so that their skills and experience are valuable for a variety of positions in both industry and research. |
Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates
On successful completion of this unit, you will be able to:
Assignments
All assignments must be submitted as soft copy on the date specified.
All written work must be submitted to Turnitin for plagiarism checking. Instructions will be provided on iLearn.
Criteria and standards required for the assessment tasks will be available on iLearn.
Note the standardised 5 pm submission time for assessments
Extensions will only be granted under exceptional circumstances.
Late submissions - Late submissions will be accepted for all assessments in this unit with penalties. There will be a deduction of 10% of the total available marks made from the total awarded mark for each 24 hour period or part thereof that the submission is late (for example, 25 hours late in submission – 20% penalty). This penalty does not apply for cases in which an application for disruption of studies is made and approved.
General Faculty Policy on assessment submission deadlines and late submissions: Online quizzes, in-class activities, or scheduled tests and exam must be undertaken at the time indicated in the unit guide. Should these activities be missed due to illness or misadventure, students may apply for Special Consideration.
All other assessments must be submitted by 11 pm on their due date. Should these assessments be missed due to illness or misadventure, students should apply for Special Consideration. As late submissions are permitted as indicated in the unit guide and on iLearn a consistent penalty will be applied for late submissions as follows: 24 hours late = 10% deduction; for each day thereafter, an additional 10% per day or part thereof will be applied until five days beyond the due date. After this time, a mark of zero (0) will be given.
Off-shore students Off-shore students must email the convenor as soon as possible to discuss study options as this course has in person practical classes and attendance is mandatory. So this course cannot be completed off-shore.
COVID Information and on-campus classes On-campus teaching continues to be scheduled for Session 1, 2022. Masks are compulsory for all classes in indoor spaces and social distancing will be implemented wherever possible. Students will also be required to sanitise surfaces before and after use. Students are requested to minimise the risk of spreading COVID to themselves and others in accordance with the university and NSW Health guidelines: https://www.mq.edu.au/about/coronavirus-faqs and https://www.nsw.gov.au/covid-19/stay-safe.
Any further requirements or changes to units in relation to COVID will be communicated to students via iLearn.
Problem Set
Problems 1 - 12 will be discussed on ongoing basis during the various practical sessions.
Requirements
Assessment tasks involve the practical assignments and the problem sets which are both integral components of the unit. Apart from the marks formally allocated to these components, a comprehensive understanding of them will greatly assist you in the final exam. You should remember that the final exam covers ALL components of the unit. Participation in ALL practical sessions is required in order to complete the practical reports.
COVID-Safe requirements
The safety of students and staff is our primary concern, and we must all work together to maintain a COVID-free campus. We ask students to note the following:
Name | Weighting | Hurdle | Due |
---|---|---|---|
Lab reports | 35% | No | Week 6, Week 8 and Week 13 |
Synthetic Biology Challenge | 15% | No | Week 13 |
Final Examination | 40% | No | TBC |
Midsemester Test | 10% | No | Week 7 April 4th 2022 |
Assessment Type 1: Lab report
Indicative Time on Task 2: 30 hours
Due: Week 6, Week 8 and Week 13
Weighting: 35%
Three lab reports 1500 words each
Assessment Type 1: Qualitative analysis task
Indicative Time on Task 2: 10 hours
Due: Week 13
Weighting: 15%
Written report based on the design phase of synthetic biology
Assessment Type 1: Examination
Indicative Time on Task 2: 18 hours
Due: TBC
Weighting: 40%
Final Examination held in university examination period
Assessment Type 1: Quiz/Test
Indicative Time on Task 2: 10 hours
Due: Week 7 April 4th 2022
Weighting: 10%
Test carried out during regularly scheduled laboratory time.
1 If you need help with your assignment, please contact:
2 Indicative time-on-task is an estimate of the time required for completion of the assessment task and is subject to individual variation
Classes
There are two weekly lectures of 1 hour each on Monday 1-2pm and Tuesday 1-2pm which will be held at 14 Sir Christopher Ondaatje Avenue Lecture Theatre 5 (14SCO T5). There is one weekly practical session of 3 hours on Monday 10-1pm (practical groups 1 and 2) and Monday 2-5pm (practical groups 3 and 4) at 14 Eastern Road Science Labs 130 and 150. Attendance at practical sessions is a compulsory component of this unit. Lecture recordings and graphics slides are available online through iLearn (https://ilearn.mq.edu.au/login/ MQ/), although lecture attendance in person is highly recommended. The practical manual is also available online through iLearn.
Required and Recommended Texts
The course syllabus is defined by all of the subject material presented in lectures and practicals, much of which is beyond standard textbooks. The prescribed text for this unit is Molecular Biology Fifth edition by Robert F Weaver. Available from the Co-op bookshop. The following texts may also be useful and are available in the library:
GenesIX by Benjamin Lewin
Mobile Genetic Elements by Sherratt
Molecular Cloning: A Laboratory Manual by Maniatis, Fritsch and Sambrook
An Introduction to Genetic Engineering by Des Nicholl.
Technology Requirements
Within this Unit, you will be introduced to web-based search engines that are commonly used in molecular biology. Our expectation is that you will be able to readily access the internet and have a computer available to you for web browsing and preparation of your laboratory reports. Handwritten reports will not be accepted. Your laboratory reports will be submitted and circulated via the online Turnitin program on iLearn, for which access instructions will be given at submission time. Your practical reports will require you to carry out minor computational tasks, for which a calculator and access to basic statistical tools will be required. We place a large emphasis on correct referencing style in all your reports, and use of the program EndNote is encouraged, but not essential.
Week |
Date |
Lecture |
Title |
Lecturer |
1 |
Feb 21 |
1 |
Introduction/What is Molecular Biology/Genome Structure |
Haynes |
Feb 22 |
2 |
Gene Organization/function |
Haynes |
|
2 |
Feb 28 |
3 |
Molecular Biology Techniques |
Haynes |
Mar 1 |
4 |
Molecular Biology Techniques |
Haynes |
|
3 |
Mar 7 |
5 |
Molecular Cloning |
Haynes |
Mar 8 |
6 |
Tools for studying Gene Activity |
Haynes |
|
4 |
Mar 14 |
7 |
Transcription in Prokaryotes |
Paulsen |
Mar 15 |
8 |
Structure of Prokaryotic Operons |
Paulsen |
|
5 |
Mar 21 |
9 |
Bacterial Gene Regulation |
Paulsen |
Mar 22 |
10 |
Transcription in Eukaryotes |
Paulsen |
|
6 |
Mar 28 |
11 |
Eukaryotic Gene Regulation |
Paulsen |
Mar 29 |
12 |
Nucleosomes/Histones/Chromatin |
Paulsen |
|
7 |
Apr 4 |
13 |
Messenger RNA splicing |
Paulsen |
Apr 5 |
14 |
Mechanism of Translation |
Paulsen |
|
SEMESTER BREAK
|
||||
8 |
Apr 26 |
15 |
Ribosomes and transfer RNA |
Paulsen |
9 |
May 2 |
16 |
DNA replication |
Paulsen |
May 3 |
17 |
DNA recombination |
Paulsen |
|
10 |
May 9 |
18 |
DNA Repair |
Paulsen |
May 10 |
19 |
Mobile DNA elements #1 |
Paulsen |
|
11 |
May 16 |
20 |
Mobile DNA elements #2 |
Paulsen |
May 17 |
21 |
Genome Sequencing |
Paulsen |
|
12 |
May 23 |
22 |
Genomes, Pan-Genomes and Metagenomics |
Paulsen |
May 24 |
23 |
Bioinformatics and Genome Annotation |
Paulsen |
|
13 |
May 30 |
24 |
Functional Genomics and Systems Biology |
Paulsen |
May 31 |
25 |
Synthetic Biology |
Paulsen |
Macquarie University policies and procedures are accessible from Policy Central (https://policies.mq.edu.au). Students should be aware of the following policies in particular with regard to Learning and Teaching:
Students seeking more policy resources can visit Student Policies (https://students.mq.edu.au/support/study/policies). It is your one-stop-shop for the key policies you need to know about throughout your undergraduate student journey.
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At Macquarie, we believe academic integrity – honesty, respect, trust, responsibility, fairness and courage – is at the core of learning, teaching and research. We recognise that meeting the expectations required to complete your assessments can be challenging. So, we offer you a range of resources and services to help you reach your potential, including free online writing and maths support, academic skills development and wellbeing consultations.
Macquarie University provides a range of support services for students. For details, visit http://students.mq.edu.au/support/
The Writing Centre provides resources to develop your English language proficiency, academic writing, and communication skills.
The Library provides online and face to face support to help you find and use relevant information resources.
Macquarie University offers a range of Student Support Services including:
Got a question? Ask us via AskMQ, or contact Service Connect.
For help with University computer systems and technology, visit http://www.mq.edu.au/about_us/offices_and_units/information_technology/help/.
When using the University's IT, you must adhere to the Acceptable Use of IT Resources Policy. The policy applies to all who connect to the MQ network including students.
The Bioinformatic Project is now run as a Synthetic Biology Design Challenge (see iLearn and the Prac Manual for details). It now runs from week 2 to week 13 in prac classes, rather than being in a discrete period (weeks 9-11) as previous.
Unit information based on version 2022.03 of the Handbook