Unit convenor and teaching staff |
Unit convenor and teaching staff
Alison Rodger
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Credit points |
Credit points
10
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Prerequisites |
Prerequisites
Admission to MRes
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Corequisites |
Corequisites
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Co-badged status |
Co-badged status
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Unit description |
Unit description
This unit outlines molecular principles underlying today's developments in protein science and biomedical research. As well as detailing modern separation technologies, the course addresses structural biology, protein analysis and bioinformatics. Practices common in the biotechnology and pharmaceutical industries to isolate recombinant proteins are emphasized. Analysis methods are introduced in relation to proteomics, genomics and biochemical research. Molecular properties leading to the 3D shape of proteins are detailed and contemporary structure methods outlined.
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Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates
On successful completion of this unit, you will be able to:
Requirements to Pass this Unit: MOLS8211/7211 is a completely assessment-based unit. To past you must get 50% of higher.
Late Assessment Submission Penalty: Unless a Special Consideration request has been submitted and approved, a 5% penalty (of the total possible mark of the task) will be applied for each day a written assessment is not submitted, up until the 7th day (including weekends). After the 7th day, a grade of ‘0’ will be awarded even if the assessment is submitted. The submission time for all uploaded assessments is 11:55 pm. A 1-hour grace period will be provided to students who experience a technical problem.
Postponement of the final Pet Protein presentation requires an approved Special Consideration.
Assessments where Late Submissions will be accepted with standard late penalties: all written assignments except quizes
Assessments where Late Submissions will NOT be accepted: quizes and the presentation
Name | Weighting | Hurdle | Due |
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In class quizzes | 40% | No | Weeks 3, 7, 9, 11 |
"Pet Protein" Sequence Analysis & Purification | 15% | No | Week 5 |
Molecular graphics | 10% | No | Week 6 |
Protein Production Practical | 15% | No | Week 9 |
“Pet Protein” Model and Seminar | 20% | No | Week 12, 13 |
Assessment Type 1: Quiz/Test
Indicative Time on Task 2: 25 hours
Due: Weeks 3, 7, 9, 11
Weighting: 40%
Short answer quizzes for continual assessment
Assessment Type 1: Case study/analysis
Indicative Time on Task 2: 15 hours
Due: Week 5
Weighting: 15%
Each student will be assigned a protein of industrial/medical importance as a case study throughout this Unit. You will conduct a literature search to discover the purification procedures historically used to isolate this protein, and report on the background chemistry underlying these procedures.
Assessment Type 1: Case study/analysis
Indicative Time on Task 2: 14 hours
Due: Week 6
Weighting: 10%
You will use molecular graphics (program PyMOL) to view the 3D structure of a GTP-ase protein to understand its binding and function.
Assessment Type 1: Lab report
Indicative Time on Task 2: 10 hours
Due: Week 9
Weighting: 15%
Follow the procedures for preparation and isolation of a protein, and analyse the characteristics of your sample.
Assessment Type 1: Creative work
Indicative Time on Task 2: 20 hours
Due: Week 12, 13
Weighting: 20%
Research the literature concerning the 3D structure and structure determination method for your assigned protein. Construct a model that shows the three-dimensional shape of this macromolecule, and present this in a class presentation.
1 If you need help with your assignment, please contact:
2 Indicative time-on-task is an estimate of the time required for completion of the assessment task and is subject to individual variation
Protein structure and function are intrinsically related, so it is important to be able to produce pure protein that is correctly folded into the correct shape for its biological activity. The goal of this unit is to lead you to understand how to do this, how to prove you have done it, and how the correct structure relates to protein's function.
This unit outlines molecular principles underlying today's developments in protein science and biomedical research. As well as detailing modern separation technologies, the course addresses structural biology, protein analysis and bioinformatics. Practices common in the biotechnology and pharmaceutical industries to isolate recombinant proteins are emphasized. Analysis methods are introduced in relation to proteomics, genomics and biochemical research. Molecular properties leading to the 3D shape of proteins are detailed, and contemporary structure methods outlined.
The assessed work for the unit includes skills-based workshops and a block laboratory class in the mid semester break. These are designed to give you the skills to enable you to understand the origin, structure and function of your pet protein - which you will be assigned early in the unit. The unit runs from week 1 to week 13 and includes a practical session in the mid semester break. Each week on Tuesday afternoons from 2 pm to 5 pm. We formally have 2 lectures and 1 SGTA. It should be noted that lectures include problem solving and SGTAs will include some content delivery. You are strongly advised to organise your timetable to be present for all the contact hours of this unit.
The unit convenor may be contacted by email. Please use MOLS8211/7211 in the subject line to avoid your email getting lost. In an emergency you coudl try texting or phoning her: 0426627077.
For the latest information on the University’s response to COVID-19, please refer to the Coronavirus infection page on the Macquarie website: https://www.mq.edu.au/about/coronavirusfaqs. Remember to check this page regularly in case the information and requirements change during semester. If there are any changes to this unit in relation to COVID, these will be communicated via iLearn. You will be required to wear a mask during laboratory sessions and implement hand and bench hygene measures.
Macquarie University policies and procedures are accessible from Policy Central (https://policies.mq.edu.au). Students should be aware of the following policies in particular with regard to Learning and Teaching:
Students seeking more policy resources can visit Student Policies (https://students.mq.edu.au/support/study/policies). It is your one-stop-shop for the key policies you need to know about throughout your undergraduate student journey.
To find other policies relating to Teaching and Learning, visit Policy Central (https://policies.mq.edu.au) and use the search tool.
Macquarie University students have a responsibility to be familiar with the Student Code of Conduct: https://students.mq.edu.au/admin/other-resources/student-conduct
Results published on platform other than eStudent, (eg. iLearn, Coursera etc.) or released directly by your Unit Convenor, are not confirmed as they are subject to final approval by the University. Once approved, final results will be sent to your student email address and will be made available in eStudent. For more information visit ask.mq.edu.au or if you are a Global MBA student contact globalmba.support@mq.edu.au
At Macquarie, we believe academic integrity – honesty, respect, trust, responsibility, fairness and courage – is at the core of learning, teaching and research. We recognise that meeting the expectations required to complete your assessments can be challenging. So, we offer you a range of resources and services to help you reach your potential, including free online writing and maths support, academic skills development and wellbeing consultations.
Macquarie University provides a range of support services for students. For details, visit http://students.mq.edu.au/support/
The Writing Centre provides resources to develop your English language proficiency, academic writing, and communication skills.
The Library provides online and face to face support to help you find and use relevant information resources.
Macquarie University offers a range of Student Support Services including:
Got a question? Ask us via AskMQ, or contact Service Connect.
For help with University computer systems and technology, visit http://www.mq.edu.au/about_us/offices_and_units/information_technology/help/.
When using the University's IT, you must adhere to the Acceptable Use of IT Resources Policy. The policy applies to all who connect to the MQ network including students.
Date | Description |
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03/02/2023 | Only changed some submission dates |
Unit information based on version 2023.01R of the Handbook