Students

BMOL3202 – Macromolecules

2025 – Session 2, In person-scheduled-weekday, North Ryde

General Information

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Unit convenor and teaching staff Unit convenor and teaching staff Unit Convenor
Bhumika Shah
6WW 208
By appointment
Credit points Credit points
10
Prerequisites Prerequisites
130cp at 1000 level or above including CHEM2201 or BMOL2201
Corequisites Corequisites
Co-badged status Co-badged status
BMOL6202
Unit description Unit description

This unit outlines molecular principles underlying macromolecules and nano-materials that find a wide range of applications from nanotechnology, biomedical research, to bio-engineering. Practices common in these fields to design, prepare, synthesise and then isolate new materials will be emphasized. Molecular properties leading to the 3D shape of macromolecules will be reviewed. Contemporary structural and imaging based methods to view and characterise macromolecules, both natural and synthetic, will be examined. In particular, attention will be given to the chemical, biochemical and structural characterisation of the building blocks of the living world including nucleic acids, proteins, and polysaccharides. Recent advances and landmark reports from the current literature will be examined. The unit will be delivered through workshops, seminars, lab work and project-based learning.

Learning in this unit enhances student understanding of global challenges identified by the United Nations Sustainable Development Goals (UNSDGs) Good Health and Well Being; Quality Education; Industry, Innovation and Infrastructure

Important Academic Dates

Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates

Learning Outcomes

On successful completion of this unit, you will be able to:

  • ULO1: Describe and apply the underlying principles for synthesising and engineering macromolecules and other synthetic particle-based nanomaterials. Apply this knowledge to design and conduct experiments to synthesise macromolecules in the laboratory.
  • ULO2: Describe bio-macromolecular forms and architectures (size/shape) for proteins, sugars and nucleotides.
  • ULO3: Interpret and draw sound conclusions from analytical and biophysical data.
  • ULO4: Describe the principles of contemporary analytical tools to image and characterise the structural features of bio-macromolecules and synthetic macromolecules. Utilise these techniques to collect experimental data on one or more macromolecule.
  • ULO5: Apply basic concepts from thermodynamics and kinetics to interpret molecular mechanisms of macromolecule systems.
  • ULO6: Extract and interpret information from a variety of sources concerning macromolecules, including the contemporary scientific literature.

General Assessment Information

Requirements to Pass this Unit

To pass this unit you need to:

  • Achieve a total mark equal to or greater than 50% across all assessments

 

Attendance and participation

We strongly encourage all students to actively participate in all learning activities. Regular engagement is crucial for your success in this unit, as these activities provide opportunities to deepen your understanding of the material, collaborate with peers, and receive valuable feedback from instructors, to assist in completing the unit assessments. Your active participation not only enhances your own learning experience but also contributes to a vibrant and dynamic learning environment for everyone.

 

Late Assessment Submission Penalty 

From 1 July 2022, Students enrolled in Session based units with written assessments will have the following university standard late penalty applied. Please see https://students.mq.edu.au/study/assessment-exams/assessments for more information. 

Unless a Special Consideration request has been submitted and approved, a 5% penalty (of the total possible mark) will be applied each day a written assessment is not submitted, up until the 7th day (including weekends). After the 7th day, a grade of '0' will be awarded even if the assessment is submitted. Submission time for all written assessments is set at 11:55 pm. A 1-hour grace period is provided to students who experience a technical concern. 

 For any late submission of time-sensitive tasks, such as scheduled tests/exams, performance assessments/presentations, and/or scheduled practical assessments/labs, students need to submit an application for Special Consideration.  

 

Assessments where Late Submissions will be accepted: 

In this unit, late submissions will accepted as follows: 

LABORATORY BOOK - Yes, standard late penalty applies (unless Special Consideration is granted). 

CASE STUDY REPORT - Yes, standard late penalty applies (unless Special Consideration is granted). 

CASE STUDY ORAL PRESENTATION - NO, unless Special Consideration is granted. 

 

Special Consideration

The Special Consideration Policy aims to support students who have been impacted by short-term circumstances or events that are serious, unavoidable and significantly disruptive, and which may affect their performance in assessment. If you experience circumstances or events that affect your ability to complete the assessments in this unit on time, please inform the convenor and submit a Special Consideration request through https://connect.mq.edu.au.

Assessment Tasks

Name Weighting Hurdle Due
Case study 20% No Week 13
Lab book 40% No Week 12
Final Exam 40% No Exam Period

Case study

Assessment Type 1: Case study/analysis
Indicative Time on Task 2: 20 hours
Due: Week 13
Weighting: 20%

 

A presentation and a written overview on the topic of a contemporary macromolecule will be prepared in small groups. Half of the marks are for the group and half the marks are for your individual contribution. A marking rubric will be provided on iLearn.

 


On successful completion you will be able to:
  • Describe bio-macromolecular forms and architectures (size/shape) for proteins, sugars and nucleotides.
  • Describe the principles of contemporary analytical tools to image and characterise the structural features of bio-macromolecules and synthetic macromolecules. Utilise these techniques to collect experimental data on one or more macromolecule.
  • Extract and interpret information from a variety of sources concerning macromolecules, including the contemporary scientific literature.

Lab book

Assessment Type 1: Lab book
Indicative Time on Task 2: 34 hours
Due: Week 12
Weighting: 40%

 

A completed lab book containing the experimental results and demonstrating appropriate continual data collection during lab classes will be submitted after completion of the final laboratory session for the semester. Lab books will be signed off by a demonstrator prior to leaving each lab class. See iLearn for a marking rubric and expectations for the lab book.

 


On successful completion you will be able to:
  • Describe and apply the underlying principles for synthesising and engineering macromolecules and other synthetic particle-based nanomaterials. Apply this knowledge to design and conduct experiments to synthesise macromolecules in the laboratory.
  • Interpret and draw sound conclusions from analytical and biophysical data.
  • Describe the principles of contemporary analytical tools to image and characterise the structural features of bio-macromolecules and synthetic macromolecules. Utilise these techniques to collect experimental data on one or more macromolecule.
  • Apply basic concepts from thermodynamics and kinetics to interpret molecular mechanisms of macromolecule systems.

Final Exam

Assessment Type 1: Examination
Indicative Time on Task 2: 20 hours
Due: Exam Period
Weighting: 40%

 

The final examination will cover all sections of the unit (lectures, lab practicals, workshops and assignments) and is designed to address specific understanding of all the concepts presented within the course.

 


On successful completion you will be able to:
  • Describe and apply the underlying principles for synthesising and engineering macromolecules and other synthetic particle-based nanomaterials. Apply this knowledge to design and conduct experiments to synthesise macromolecules in the laboratory.
  • Describe bio-macromolecular forms and architectures (size/shape) for proteins, sugars and nucleotides.
  • Interpret and draw sound conclusions from analytical and biophysical data.
  • Describe the principles of contemporary analytical tools to image and characterise the structural features of bio-macromolecules and synthetic macromolecules. Utilise these techniques to collect experimental data on one or more macromolecule.
  • Apply basic concepts from thermodynamics and kinetics to interpret molecular mechanisms of macromolecule systems.

1 If you need help with your assignment, please contact:

  • the academic teaching staff in your unit for guidance in understanding or completing this type of assessment
  • the Writing Centre for academic skills support.

2 Indicative time-on-task is an estimate of the time required for completion of the assessment task and is subject to individual variation

Delivery and Resources

Methods of Communication: We will communicate with you via your university email and through announcements on iLearn. Queries to convenors can either be placed on the iLearn discussion board or sent to the unit convenor via the contact email on iLearn.

COVID Information: For the latest information on the University’s response to COVID-19, please refer to the Coronavirus infection page on the Macquarie website: https://www.mq.edu.au/about/coronavirus-faqs. Remember to check this page regularly in case the information and requirements change during semester. If there are any changes to this unit in relation to COVID, these will be communicated via iLearn.

Week1 Classes: During Week1, we have two 1-hr Letcures as scheduled in the timetable. 

Lectures: There are two lectures per week as per the university timetable. Lectures are delivered on-campus and will also be recorded. All lecture material will be made available on iLearn.

Workshop Sessions (Dry-lab, 2 hrs): There are five scheduled on-campus workshop sessions in total. Workshops 1-3 will include a non-assessable quiz, facilitating engagement and early feedback. There is an optional workshop (workshop 4) to assist with Laboratory Book assessment. Case study oral presentations will be conducted during Workshop 5.

SGTA (1 hr): SGTAs will be held during the scheduled workshop sessions (3 hrs - 1 hr SGTA + 2 hr Workshops) on-campus in Weeks 5,7,9, 11 and 13. Each SGTA session will involve a 30 min discussion followed by a non-assessable quiz (except week 13).

Laboratory Sessions (Wet-lab): 3 hour Laboratory sessions are scheduled according to the timetable. There are two timetabled sessions available.

Practicals 1 - 4 will be held on-campus at Science labs in 14 Sir Christopher Ondaatje Ave (E7B) 349+350 Science Lab. In total, there are FOUR lab sessions held in weeks 4, 6, 8 and 10. Attendance at all four laboratory sessions is required to collect data to complete the Lab book assessment (40%). If you cannot attend, you must submit a Special Consideration request if you wish your absence to be considered.

** Students must bring their own lab coats to be allowed to enter the labs. It is also recommended that students bring their own safety glasses. However, these will be provided if students to not have their own safety glasses. Other PPE will be provided.

Case study presentations: Will be held during the scheduled SGTA/Workshop session in Week 13. A short presentation (~ 10 mins) will be given in small groups on the topic of a contemporary macromolecule. Half of the marks are for the group and half the marks are for your individual contribution, to be submitted on the day of presentation. If you cannot attend, a Special Consideration request must be submitted if you wish your absence to be considered.

** It is a requirement that students bring their own laptops to workshop sessions held on-campus. Please ensure your laptop is fully charged as powerpoints may not be available for all students. If you require a loan of a laptop, this can be arranged PRIOR to the workshop session by contacting the unit convenor. 

 

Textbooks: Reading material and required text will be advised by your lecturer. A list of suggested reading material and text will be made available on iLearn and through the library website https://libguides.mq.edu.au/leganto.

Unit Schedule

S2

Wk

Week starting Lecture 1   Lecture 2   Workshop/SGTA sessions Practical (on campus) Assessments Due
23 Wally's Walk T2 Lecture Theatre  10 Hadenfeld Avenue T1 Lecture Theatre  (on campus, see timetable)    
Monday: 10-11 a.m Tuesday 9 - 10 a.m Mon 1 - 4 p.m (1-2 p.m SGTA; 2-4 p.m Workshop); 25WW A208 OR Thurs 1 - 4 p.m (1-2 p.m SGTA; 2-4 p.m Workshop); 25WW A207

Wed 9-12 pm OR Wed 1-4 pm

Held in 14 Sir Christopher Ondaatje Ave - 349 + 350 Labs

 
1 28-Jul Introduction to Unit BS Introduction to Topic BS   -    -   -
2 4-Aug Chemistry of non-covalent Interactions BS Chemistry of non-covalent Interactions BS   -    -   -
3 11-Aug Folding & stability of macromolecules in solution BS Folding & stability of macromolecules in solution BS -   -   -
4 18-Aug Folding & stability of macromolecules in solution BS Biological Macromolecules - Proteins BS   -  Prac 1: Cyclodextrin Host-Guest Chemistry  -
5 25-Aug Biological Macromolecules - Proteins BS Biological Macromolecules - Proteins BS #SGTA 1; WS1: WorkshopFold IT (on campus)    -   -
6 1-Sep Biological Macromolecules - Carbohydrates MA Synthesis & self-assembly AGB   -  Prac 2: Protein Unfolding/Circular Dichrosism -
7 8-Sep Synthesis & self-assembly AGB Synthesis & self-assembly AGB #SGTA 2; WS2: Biomolecules workshop Part A  (on campus)    -   -
8 15-Sep Characterising Macromolecules - Molecular Mass BS Characterising Macromolecules - Optical methods BS   -  Prac 3: Spectroscopic characterisation of amyloid fibril formation by lysozyme -
     Mid-semester break: 22 September - 6 October, 2025 
9 6-Oct Public holiday - Special Topics: Molecules built to specific shapes - NanoParticles YW #SGTA 3; WS3: Biomolecules workshop Part B  (on campus)   - -
10 13-Oct Characterising Macromolecules - Scattering methods AGB Characterising Macromolecules - Electron Microscopy AGB   -  Prac 4: Making and characterisation of nanogold particles  -
11 20-Oct Characterising Macromolecules - Fluorescence microscopy and X-Ray BS Characterising Macromolecules - Other methods BS #SGTA 4; WS4: Extra Lab book help session (optional)   -  -
12 27-Oct Special Topics: Molecules built to specific shapes - NanoDiamonds BS Special Topics: Molecules built to specific shapes - Nucleic acids BS   -   - Lab Book (40%)
13 3-Nov Special Topics: Molecules built to specific shapes - Biomimetics BS Course Summary; Q&A BS #WS5. Case studies: Oral Presentations (on campus)   - Case study Oral and written overview (20%)
    Lecturer code: BS - Dr Bhumika Shah, YW - Prof. Yuling Wang; AGB - A/Prof. Alf Garcia Bennett; MA - A/Prof. Morten Andersen  
    ***Schedule is subject to change as the semester progresses  
    The unit guides below contain important information about scheduling of activities, assessments and other important policies such as the special consideration policy. Please read this document carefully.  

Policies and Procedures

Macquarie University policies and procedures are accessible from Policy Central (https://policies.mq.edu.au). Students should be aware of the following policies in particular with regard to Learning and Teaching:

Students seeking more policy resources can visit Student Policies (https://students.mq.edu.au/support/study/policies). It is your one-stop-shop for the key policies you need to know about throughout your undergraduate student journey.

To find other policies relating to Teaching and Learning, visit Policy Central (https://policies.mq.edu.au) and use the search tool.

Student Code of Conduct

Macquarie University students have a responsibility to be familiar with the Student Code of Conduct: https://students.mq.edu.au/admin/other-resources/student-conduct

Results

Results published on platform other than eStudent, (eg. iLearn, Coursera etc.) or released directly by your Unit Convenor, are not confirmed as they are subject to final approval by the University. Once approved, final results will be sent to your student email address and will be made available in eStudent. For more information visit connect.mq.edu.au or if you are a Global MBA student contact globalmba.support@mq.edu.au

Academic Integrity

At Macquarie, we believe academic integrity – honesty, respect, trust, responsibility, fairness and courage – is at the core of learning, teaching and research. We recognise that meeting the expectations required to complete your assessments can be challenging. So, we offer you a range of resources and services to help you reach your potential, including free online writing and maths support, academic skills development and wellbeing consultations.

Student Support

Macquarie University provides a range of support services for students. For details, visit http://students.mq.edu.au/support/

Academic Success

Academic Success provides resources to develop your English language proficiency, academic writing, and communication skills.

The Library provides online and face to face support to help you find and use relevant information resources. 

Student Services and Support

Macquarie University offers a range of Student Support Services including:

Student Enquiries

Got a question? Ask us via the Service Connect Portal, or contact Service Connect.

IT Help

For help with University computer systems and technology, visit http://www.mq.edu.au/about_us/offices_and_units/information_technology/help/

When using the University's IT, you must adhere to the Acceptable Use of IT Resources Policy. The policy applies to all who connect to the MQ network including students.

Changes from Previous Offering

To enable students more time to focus on learning, understanding and reflecting on the content of our unit we have revised the assessment structure as follows. There are now only three assessments: a case study (20%), Full Laboratory book (40%) and final exam (40%).

Although no marks are associated with attendance, all activities provide you with key content designed to help you understand content and complete the assessments.


Unit information based on version 2025.04 of the Handbook