Students

CHEM3801 – Medicinal Chemistry

2025 – Session 1, In person-scheduled-weekday, North Ryde

General Information

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Unit convenor and teaching staff Unit convenor and teaching staff Unit Convenor and Lecturer
Andrew Piggott
Contact via 9850 8251
4WW 334
By appointment (please email)
Lecturer
Joanne Jamie
Contact via 9850 8283
4WW 231
By appointment (please email)
Lecturer
Koushik Venkatesan
Contact via 9850 8296
4WW 123
By appointment (please email)
Credit points Credit points
10
Prerequisites Prerequisites
CHEM2601 and 10cp in CBMS or BMOL or CHEM units at 2000 level or above
Corequisites Corequisites
Co-badged status Co-badged status
Unit description Unit description

Medicinal chemistry is a multidisciplinary field at the interface of chemistry, biology and pharmacology that focuses on the discovery, design and development of new and more effective pharmaceutical agents (drugs). This unit provides a comprehensive description of the fundamental principles underpinning modern medicinal chemistry, including drug-target interactions, pharmacokinetics and pharmacodynamics, and drug absorption, distribution, metabolism and excretion. A range of contemporary medicinal chemistry topics are covered, including strategies for identifying new drug leads from Nature, drug target identification and validation, rational drug design and lead optimisation. Selected case studies in medicinal chemistry include antibiotics, anticancer drugs and psychoactive agents. The theoretical aspects of the unit are complemented by a semester-long discovery-based laboratory project, in which students work in small teams to design, synthesise, characterise and evaluate the biological activity of a small library of antibiotic agents. The unit provides a robust foundation for those aspiring to contribute to the future of pharmaceutical innovation, blending theoretical knowledge with practical, hands-on experience.

Important Academic Dates

Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates

Learning Outcomes

On successful completion of this unit, you will be able to:

  • ULO1: Describe the fundamental chemical and biological principles underpinning medicinal chemistry in the context of modern drug discovery, design and development.
  • ULO2: Apply knowledge of medicinal chemistry principles to solve contemporary problems in drug discovery, design and development.
  • ULO3: Use the primary scientific literature and other specialist chemical databases to design and evaluate safe and efficient synthetic routes to pharmaceutical agents.
  • ULO4: Use modern laboratory equipment and techniques to synthesise, purify, characterise and evaluate the biological activity of pharmaceutical agents in a safe and efficient manner.
  • ULO5: Analyse the structures of pharmaceutical agents, assess their purity and measure their physicochemical properties.
  • ULO6: Communicate medicinal chemistry concepts and experimental results clearly and succinctly in oral presentations and in written format

General Assessment Information

Requirements to Pass this Unit

To pass this unit you must:

  • Achieve a Total Mark equal to or greater than 50%, and
  • Achieve a Mid-Session Test mark equal to or greater than 40%.

 

Hurdle Assessments

  • Mid-Semester Test (15%). To pass this unit, you will need to demonstrate ongoing development of skills and application of knowledge. This progress will be assessed in the form of a 50-minute on-campus closed-book written test covering unit content up to and including Week 7. To pass this test, you must achieve a mark equal to or greater than 40%. This is a hurdle assessment, meaning that failure to meet this requirement may result in a fail grade for the unit. Students who make a serious attempt at the test (defined as achieving a mark between 30% and 39%) but fail to clear the hurdle will be offered a second attempt in the form of a Supplementary Mid-Session Test, to be administered within 1 week of the original test.

 

Late Assessment Submission Penalty

Unless a Special Consideration request has been submitted and approved, a 5% penalty (of the total possible mark of the task) will be applied for each day a written report or presentation assessment is not submitted, up until the 7th day (including weekends). After the 7th day, a grade of ‘0’ will be awarded even if the assessment is submitted. The submission time for all uploaded assessments is 11:55 pm. A 1-hour grace period will be provided to students who experience a technical concern. For any late submission of time-sensitive tasks, such as scheduled tests/exams, performance assessments/presentations, and/or scheduled practical assessments/labs, please apply for Special Consideration.

Assessments where Late Submissions will be accepted:

  • Practical Work – YES, Standard Late Penalty applies
  • All other assessment items – NO, unless Special Consideration is Granted

 

Special Consideration

The Special Consideration Policy aims to support students who have been impacted by short-term circumstances or events that are serious, unavoidable and significantly disruptive, and which may affect their performance in assessment. If you experience circumstances or events that affect your ability to complete the assessments in this unit on time, please inform the convenor and submit a Special Consideration request through https://connect.mq.edu.au.

Assessment Tasks

Name Weighting Hurdle Due
Synthetic Routes and Risk Assessments 5% No 09/03/2025
Mid-Session Test 15% Yes 09/04/2025
Pharmaceutical Agent Presentation 10% No 21/05/2025
Laboratory Notebook 15% No 08/06/2025
Team Laboratory Report 15% No 08/06/2025
Final Examination 40% No Exam Period

Synthetic Routes and Risk Assessments

Assessment Type 1: Plan
Indicative Time on Task 2: 5 hours
Due: 09/03/2025
Weighting: 5%

 

Prior to commencing laboratory work, students will submit a detailed plan for the synthesis of their assigned pharmaceutical agents, including a comprehensive experimental method with literature references, flow charts, individual hazardous chemical risk assessments and an overarching risk assessment for the procedure.

 


On successful completion you will be able to:
  • Apply knowledge of medicinal chemistry principles to solve contemporary problems in drug discovery, design and development.
  • Use the primary scientific literature and other specialist chemical databases to design and evaluate safe and efficient synthetic routes to pharmaceutical agents.

Mid-Session Test

Assessment Type 1: Quiz/Test
Indicative Time on Task 2: 10 hours
Due: 09/04/2025
Weighting: 15%
This is a hurdle assessment task (see assessment policy for more information on hurdle assessment tasks)

 

The mid-session test will assess specific understanding of all the topics presented within the first half of the unit. The test consists of a combination of short-answer, and mechanism-based questions.

 


On successful completion you will be able to:
  • Describe the fundamental chemical and biological principles underpinning medicinal chemistry in the context of modern drug discovery, design and development.
  • Apply knowledge of medicinal chemistry principles to solve contemporary problems in drug discovery, design and development.
  • Communicate medicinal chemistry concepts and experimental results clearly and succinctly in oral presentations and in written format

Pharmaceutical Agent Presentation

Assessment Type 1: Presentation
Indicative Time on Task 2: 10 hours
Due: 21/05/2025
Weighting: 10%

 

Students will deliver a short oral presentation describing one recently approved pharmaceutical agent. Students will also provide peer feedback on the presentations of other students.

 


On successful completion you will be able to:
  • Describe the fundamental chemical and biological principles underpinning medicinal chemistry in the context of modern drug discovery, design and development.
  • Communicate medicinal chemistry concepts and experimental results clearly and succinctly in oral presentations and in written format

Laboratory Notebook

Assessment Type 1: Lab book
Indicative Time on Task 2: 15 hours
Due: 08/06/2025
Weighting: 15%

 

Students will record all experimental details and observations in an industry-standard laboratory notebook.

 


On successful completion you will be able to:
  • Use modern laboratory equipment and techniques to synthesise, purify, characterise and evaluate the biological activity of pharmaceutical agents in a safe and efficient manner.
  • Analyse the structures of pharmaceutical agents, assess their purity and measure their physicochemical properties.
  • Communicate medicinal chemistry concepts and experimental results clearly and succinctly in oral presentations and in written format

Team Laboratory Report

Assessment Type 1: Lab report
Indicative Time on Task 2: 15 hours
Due: 08/06/2025
Weighting: 15%

 

Practical work will be conducted in small teams. Each team will produce a comprehensive final report, including a written justification of their choice of target compounds and synthetic routes, a formal write-up of experimental procedures and a detailed analysis of the bioassay results and structure-activity relationship trends.

 


On successful completion you will be able to:
  • Describe the fundamental chemical and biological principles underpinning medicinal chemistry in the context of modern drug discovery, design and development.
  • Apply knowledge of medicinal chemistry principles to solve contemporary problems in drug discovery, design and development.
  • Use the primary scientific literature and other specialist chemical databases to design and evaluate safe and efficient synthetic routes to pharmaceutical agents.
  • Use modern laboratory equipment and techniques to synthesise, purify, characterise and evaluate the biological activity of pharmaceutical agents in a safe and efficient manner.
  • Analyse the structures of pharmaceutical agents, assess their purity and measure their physicochemical properties.
  • Communicate medicinal chemistry concepts and experimental results clearly and succinctly in oral presentations and in written format

Final Examination

Assessment Type 1: Examination
Indicative Time on Task 2: 15 hours
Due: Exam Period
Weighting: 40%

 

The final examination will be held during the regular university examination period at the end of semester. This examination will assess specific understanding of all the topics presented within the unit. The examination will consist of a combination of short-answer, long-answer and mechanism-based questions.

 


On successful completion you will be able to:
  • Describe the fundamental chemical and biological principles underpinning medicinal chemistry in the context of modern drug discovery, design and development.
  • Apply knowledge of medicinal chemistry principles to solve contemporary problems in drug discovery, design and development.
  • Communicate medicinal chemistry concepts and experimental results clearly and succinctly in oral presentations and in written format

1 If you need help with your assignment, please contact:

  • the academic teaching staff in your unit for guidance in understanding or completing this type of assessment
  • the Writing Centre for academic skills support.

2 Indicative time-on-task is an estimate of the time required for completion of the assessment task and is subject to individual variation

Delivery and Resources

CHEM3801 Medicinal Chemistry is a 10 credit point unit requiring 150 hours of work over the semester (formal contact hours and self study time). This is an average of 10 hours of work per week over each of the 15 weeks of semester. Formal contact hours for CHEM3801 consist of 2 hours of lectures and a 1-hour interactive SGTA per week, along with 8 x 4-hour laboratory classes throughout semester. Students are expected to participate in all lectures, SGTAs and laboratory classes. Active participation by students in all of these activities will be essential for success in the unit.

 

Lectures

NOTE: Lectures commence in Week 1

The unit will cover 2 hours of lecture material each week. Some lecture material will be available on the unit web site, while other material will be provided during the lecture classes.  You should use these lectures as a starting point and supplement their content with material from the text book, the scientific literature and from other online sources. Much of the unit content builds on content covered in previous weeks, so it will be essential to keep up to date with the lecture material throughout the semester.

 

Interactive SGTAs

NOTE: Interactive SGTAs commence in Week 2

A 1-hour interactive SGTA will be held each week from Week 2. This is your opportunity to interact directly with the teaching staff, to ask lots of pertinent questions and to identify any weaknesses or clarify misconceptions you may have. Learning is an active process, and as such, you must engage with the material. This means reading the textbook (and beyond) before and after lectures, attempting the assignment questions and discussing the concepts with your classmates and lecturers. Do not be afraid to ask questions – everyone benefits from a robust and open discussion of the topics. Five short quizzes will also be delivered throughout semester. The quizzes may include any material that has been covered in the unit up to that point, so you are expected to keep up to date with lectures and to revise course material each week. While not formally assessed, the quizzes are designed to help you to learn continuously and to identify what you understand and the areas that you need to spend more time on.

 

Laboratory Classes

NOTE: Laboratory classes commence in Week 1

Laboratory classes will be conducted in small teams and require a highly collaborative and investigative approach. You will be designing and synthesising a series of sulfonamide antibiotics and subsequently testing them for antibacterial activity to determine the important features for their antibacterial activity. This laboratory work is designed to give real-world experience in research by involving you in the design of the experiments, using literature procedures as a guide, and troubleshooting to identify the best experimental conditions. The classes will emphasise the importance of teamwork and being well prepared and efficient. You will need to be fully aware of safety procedures, proper recording and reporting of raw data and interpretation of results. This will require an analytical and inquisitive approach. The first (dry) laboratory class starts in Week 1, where you will meet your fellow team members, plan your synthetic routes and complete risk assessments. There will then be a series of wet labs sessions run throughout semester. Please refer to the iLearn site for a detailed schedule. The final (dry) laboratory class will bring all the teams back together to discuss their results and to finalise the laboratory reports. To maximise the amount of wet lab time available to complete the experiments, you will need to be highly organised and to have prepared thoroughly BEFORE entering the laboratory. If you are not able to "hit the ground running" each laboratory class, you risk running out of time by the end of semester.

 

Communication

The web page for this unit can be found at ilearn.mq.edu.au.

Login with your MQ student ID number and password, then follow the prompts to "CHEM3801 Medicinal Chemistry."

During semester, the CHEM3801 iLearn site will be used to communicate important information to you. It is your responsibility to regularly check the iLearn site for important announcements and updates.

We will communicate with you via your university email address or through the Announcements discussion board on iLearn. Queries to convenors can either be placed on the iLearn discussion board or emailed directly to the Unit Convenor from your university email address.

 

Unit Text Book

"An Introduction to Medicinal Chemistry" by Graham L. Patrick, Seventh Edition, Oxford University Press 2023. Note: The 6th edition is also acceptable.

The text book may be purchased from www.booktopia.com.au or other book shops. Limited copies of the text book are also available in the MQ Library.

Unit Schedule

Please check the unit iLearn page for the most up-to-date Unit Schedule.

Policies and Procedures

Macquarie University policies and procedures are accessible from Policy Central (https://policies.mq.edu.au). Students should be aware of the following policies in particular with regard to Learning and Teaching:

Students seeking more policy resources can visit Student Policies (https://students.mq.edu.au/support/study/policies). It is your one-stop-shop for the key policies you need to know about throughout your undergraduate student journey.

To find other policies relating to Teaching and Learning, visit Policy Central (https://policies.mq.edu.au) and use the search tool.

Student Code of Conduct

Macquarie University students have a responsibility to be familiar with the Student Code of Conduct: https://students.mq.edu.au/admin/other-resources/student-conduct

Results

Results published on platform other than eStudent, (eg. iLearn, Coursera etc.) or released directly by your Unit Convenor, are not confirmed as they are subject to final approval by the University. Once approved, final results will be sent to your student email address and will be made available in eStudent. For more information visit connect.mq.edu.au or if you are a Global MBA student contact globalmba.support@mq.edu.au

Academic Integrity

At Macquarie, we believe academic integrity – honesty, respect, trust, responsibility, fairness and courage – is at the core of learning, teaching and research. We recognise that meeting the expectations required to complete your assessments can be challenging. So, we offer you a range of resources and services to help you reach your potential, including free online writing and maths support, academic skills development and wellbeing consultations.

Student Support

Macquarie University provides a range of support services for students. For details, visit http://students.mq.edu.au/support/

The Writing Centre

The Writing Centre provides resources to develop your English language proficiency, academic writing, and communication skills.

The Library provides online and face to face support to help you find and use relevant information resources. 

Student Services and Support

Macquarie University offers a range of Student Support Services including:

Student Enquiries

Got a question? Ask us via the Service Connect Portal, or contact Service Connect.

IT Help

For help with University computer systems and technology, visit http://www.mq.edu.au/about_us/offices_and_units/information_technology/help/

When using the University's IT, you must adhere to the Acceptable Use of IT Resources Policy. The policy applies to all who connect to the MQ network including students.

Changes from Previous Offering

We value student feedback and continually strive improve the way we offer our units. As such, we encourage students to provide constructive feedback via student surveys, to the teaching staff directly, or via the FSE Student Experience & Feedback link in the iLearn page. Student feedback from the previous offering of this unit was very positive and as such there have been no significant changes from the previous offering. However, we have made the following minor changes in response to student feedback:

  • Short Quizzes (previously worth 5% of the unit total) will no longer be formally assessed. However, students are strongly encouraged to complete all quizzes to receive valuable formative feedback from the teaching staff.
  • The weighting of the Oral Presentation has been increased from 5% to 10% to better reflect the workload associated with this assessment item.

Unit information based on version 2025.02 of the Handbook