Unit convenor and teaching staff |
Unit convenor and teaching staff
Unit Convenor, lecturer and lab demonstrator
Joanne Jamie
Contact via joanne.jamie@mq.edu.au
F7B231
Have an open door policy, but students are encouraged to arrange a meeting via email.
Lecturer
Andrew Piggott
Contact via andrew.piggott@mq.edu.au
F7B334
Have an open door policy, but students are encouraged to arrange a meeting via email.
|
---|---|
Credit points |
Credit points
4
|
Prerequisites |
Prerequisites
(Admission to MBiotech or MBioBus or MLabQAMgt or MRadiopharmSc or MSc) and permission by special approval
|
Corequisites |
Corequisites
|
Co-badged status |
Co-badged status
co-badged with CBMS306
|
Unit description |
Unit description
Medicinal chemistry is the application of chemistry to the discovery, design and synthesis of new drugs. This unit is of value to all chemistry, biomolecular sciences and medical sciences students. The central core of the unit is the description of methods used for the discovery of new drugs, how these are modified to produce more active compounds, transportation to and from their points of action and how they are cleared from the body. Topics include: the structure and function of biological targets (proteins and DNA); sources of new drugs from nature; and lead generation and methods of lead modification to make more active, selective or less toxic drugs. This is followed by a study of structure – activity relationship methods; pharmacokinetics, drug metabolism and prodrugs, and chemical genetics. Case studies are also provided, including antibacterial and anticancer agents, and nucleic acid therapies. The theory is complemented by a discovery-based laboratory project incorporating synthetic chemistry, spectroscopic methods and bioassays to elucidate the essential structural features necessary for the sulfonamide class of antibacterial agents.
|
Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates
On successful completion of this unit, you will be able to:
Your marks (in-class and online quizzes, mid-term exam, laboratory and final exam) will be placed on the CBMS606 web site.
Your final grade will be based on the mark from the aggregation of the individual assessments, with 50% or greater needed overall for a pass.
Medical certificates or official documents must be lodged as part of a disruption to studies request at ask.mq.edu.au as soon as possible if you are absent for any of the assessment tasks or miss the due date for any of the on-line tasks or the assignment. If your reason is regarded as valid for missing the in-class quizzes, you will be given an average of the other quizzes done; with the on-line quizzes and the assignment an extension of time will be provided if the disruption to studies request is approved. If you miss the mid-session test or final exam for a valid reason, a supplementary test/exam will be provided. An extension for submission of the lab reports/lab books and pharmaceutical agent assignment will also be provided if the disruption to studies approval is obtained. Any assessment tasks not submitted on time that do not get approval through the disruption to studies request will get a 10% deduction of marks for every weekday late.
Final Examination Details: The examination timetable will be available in Draft form approximately eight weeks before the commencement of the examinations and in final form approximately four weeks before the commencement of the examinations. You are expected to present yourself for examination at the time and place designated by the University in the Examination Timetable. This could be any day after the final week of semester and up until the final day of the official examination period. It is Macquarie University policy to not set early examinations for individuals or groups of students. All students are expected to ensure that they are available until the end of the teaching semester, that is, the final day of the official examination period.
The only exception to sitting an examination at the designated time is because of documented illness or unavoidable disruption. Absence from the final exam will result in a grade of F except in the case of a genuine medical emergency or misadventure as defined by the University (see below). In these circumstances you should apply for a supplementary exam at ask.mq.edu.au.
NOTE: If you receive special consideration for the final exam, a supplementary exam will be scheduled in the interval between the regular exam period and the start of the next session. By making a special consideration application for the final exam you are declaring yourself available for a resit during the supplementary examination period and will not be eligible for a second special consideration approval based on pre-existing commitments. Please ensure you are familiar with the policy prior to submitting an application. You can check the supplementary exam information page on FSE101 in iLearn (bit.ly/FSESupp) for dates, and approved applicants will receive an individual notification one week prior to the exam with the exact date and time of their supplementary examination.
Name | Weighting | Hurdle | Due |
---|---|---|---|
Practical Reports & Present'ns | 25% | No | Mar 12, Apr 13, May 16, Jun 12 |
Pharmaceutical Agent | 10% | No | May 2 |
Mid-semester test | 10% | No | May 9 |
Quizzes | 5% | No | in lectures and online |
Final exam | 50% | No | TBA |
Due: Mar 12, Apr 13, May 16, Jun 12
Weighting: 25%
The practical work (synthesis and antibacterial structure activity relationship of sulfonamides) will be conducted in groups, with ~6 people per group.
1. You will prepare a group report in the style of a journal article by midday Week 14, Tuesday June 12 (7%).
2. In the Week 3, Monday March 12 class, each group will present a short oral presentation on the justification of your group’s choice of final target compounds and possible synthetic procedures (this contributes to your participation mark at point 5).
3. In week 7 (Friday April 13 by 6pm), individual laboratory notebooks will be submitted for marking AND each group will submit a formal write up of the experimental procedure for the synthesis of one of your sulfonyl chloride-amine condensation products, including spectral data. (7.5% with 5% individual mark, 2.5% group mark).
4. In week 10, Wednesday May 16 (by midday through turnitin), each group will submit an introduction for their final lab report and discussion of their group's choice of sulfonamides, both written in journal format (3%).
5. By midday week 14, Tuesday June 12, individual laboratory notebooks will be submitted for marking. (7.5%). General safety and participation in the laboratory will also be considered in the mark.
Full details on what is expected for assessment of the practical component is provided in the laboratory manual and on the web site (see under “Laboratory Notes”).
Due: May 2
Weighting: 10%
The assignment consists of a report (10%) that summarises the chemical and biological properties of a pharmaceutical agent in current use and how these relate to its function and properties in the body, along with general historical importance of the drug. This assignment is designed to provide skills in searching the literature and understanding the properties of the pharmaceutical agent from a molecular point of view. The assignment is due Week 8, Wednesday, May 2, by midday through turnitin.
Due: May 9
Weighting: 10%
There will be a 50 minute test (/10%) in Week 9, Wednesday May 9, 8am in the lecture session. This will cover up to the end of prodrugs. This is designed to give you specific feedback on your understanding of the topics up to this stage to assist you in your further study of the unit.
Due: in lectures and online
Weighting: 5%
Short quizzes (/5%) may be conducted at any stage within the lectures. Quizzes will also be conducted online. They are to allow identification of any deficiency in knowledge and understanding and to encourage continuous learning of the lecture material without the stress of a significant assessment component.
Due: TBA
Weighting: 50%
The final exam (/50%) will be 3 hours in length with 10 minutes reading time. It is designed to assess specific understanding and holistic concepts of all the topics presented within the course and an opportunity for you to show what knowledge you have obtained and how you can apply this in new situations to solve complex problems.
The web page for this unit can be found at ilearn.mq.edu.au.
Just login and follow the prompts to CBMS606 Medicinal Chemistry.
You can use any web browser such as Firefox, Internet Explorer or Safari to login.
iLearn is the name for Macquarie University’s Learning Management System (LMS). The iLearn online learning environment enables learning, teaching, communication and collaboration. It is used to make lecture notes, laboratory notes, discussion forums, digital lecture recordings and other learning resources available to students online.
CBMS606 is a 4 credit point unit and will require an average of 10 hours of work (contact and self study time) per week over the 15 weeks. For students with weak chemistry backgrounds, more time per week will probably be necessary to perform satisfactorily in this unit. CBMS606 is run with three hours of lectures/tutorials per week, along with 4 hour blocks of laboratories/workshops. Students are required to attend all lectures, tutorials and laboratory classes. Active participation by the students in all of these fora is expected.
Further information on technology used: You are expected to access the unit web site frequently This contains important information including notes on the topics to be covered; the laboratory manual; What You Need to Know Sheets; your marks for practicals, quizzes and the mid-session exam; and past exam papers, including with answers. Additionally, the web site will also be used to post important messages and links to internet facilities and sites of relevance to the course, downloadable software, and lots of other interesting material.
If you do not have your own computer you may wish to access the Medicinal Chemistry web resources on campus using the PC computers in the Library or in the C5C computer laboratories. To view notes on all the topics and past exams on the unit web site, you will require Adobe Acrobat Reader Version 9 or later to be installed on your computer. Acrobat Reader can be downloaded from the Adobe web site http://get.adobe.com/uk/reader/. If you are using the computers in the library, then Acrobat has already been installed. Please note information will also be sent by email to your student email account so please look at your email account on a frequent basis.
You are expected to access SciFinder Scholar and Reaxys to assist in searching the literature. These are available through the library web site.
Hand-held calculators will be occasionally used in tutorials and practicals, for tests and in the final examination. Note that text-retrieval calculators are not allowed in the in-semester tests or final examination.
The first 3/4 of CBMS606 will provide an overview of the important concepts in medicinal chemistry and the last 1/4 will concentrate on case studies. CBMS606 has three hours/week allocated to lectures/tutorials. While formal lectures will be presented, discussion sessions will also form a major part of the classes. This will be supplemented by practical classes utilising synthetic chemistry, spectroscopic methods and bioassays.
The laboratory classes will be run in groups and students are required to, in part, design the experiments, using literature procedures as a guide. Considerable preparation is therefore needed. Past students have found this a valuable experience as it gives them a realistic approach to conducting research. The laboratory classes will run every week, Friday 2-6 pm except for Good Friday, the mid-session break and week 13. The week 13 lab class time will be used for the final laboratory report preparation.
In week 1, the laboratory class will be a preparative session, in which the groups will discuss structure-activity relationships and use this to rationally choose their target sulfonamides, learn how to use SciFinder Scholar and Reaxys for literature searching and start to identify key preparative methods for the sulfonamides, and prepare flow diagram and risk assessment forms for commencement of the wet laboratory classes (beginning week 2).
This week 1 preparative session will be run in the lab room E7B308 (unless otherwise indicated), and commence at 2pm. The laboratory classes will run from week 2 in laboratory E7B308/320 (unless otherwise indicated). The 2-6pm session of week 13 will be used for finalising the laboratory report and the write-up room will be available for this.
Macquarie University policies and procedures are accessible from Policy Central (https://staff.mq.edu.au/work/strategy-planning-and-governance/university-policies-and-procedures/policy-central). Students should be aware of the following policies in particular with regard to Learning and Teaching:
Undergraduate students seeking more policy resources can visit the Student Policy Gateway (https://students.mq.edu.au/support/study/student-policy-gateway). It is your one-stop-shop for the key policies you need to know about throughout your undergraduate student journey.
If you would like to see all the policies relevant to Learning and Teaching visit Policy Central (https://staff.mq.edu.au/work/strategy-planning-and-governance/university-policies-and-procedures/policy-central).
Macquarie University students have a responsibility to be familiar with the Student Code of Conduct: https://students.mq.edu.au/study/getting-started/student-conduct
Results shown in iLearn, or released directly by your Unit Convenor, are not confirmed as they are subject to final approval by the University. Once approved, final results will be sent to your student email address and will be made available in eStudent. For more information visit ask.mq.edu.au.
Macquarie University provides a range of support services for students. For details, visit http://students.mq.edu.au/support/
Learning Skills (mq.edu.au/learningskills) provides academic writing resources and study strategies to improve your marks and take control of your study.
Students with a disability are encouraged to contact the Disability Service who can provide appropriate help with any issues that arise during their studies.
For all student enquiries, visit Student Connect at ask.mq.edu.au
For help with University computer systems and technology, visit http://www.mq.edu.au/about_us/offices_and_units/information_technology/help/.
When using the University's IT, you must adhere to the Acceptable Use of IT Resources Policy. The policy applies to all who connect to the MQ network including students.
Our graduates will also be capable of creative thinking and of creating knowledge. They will be imaginative and open to experience and capable of innovation at work and in the community. We want them to be engaged in applying their critical, creative thinking.
This graduate capability is supported by:
We want our graduates to have emotional intelligence and sound interpersonal skills and to demonstrate discernment and common sense in their professional and personal judgement. They will exercise initiative as needed. They will be capable of risk assessment, and be able to handle ambiguity and complexity, enabling them to be adaptable in diverse and changing environments.
This graduate capability is supported by:
Our graduates will have enquiring minds and a literate curiosity which will lead them to pursue knowledge for its own sake. They will continue to pursue learning in their careers and as they participate in the world. They will be capable of reflecting on their experiences and relationships with others and the environment, learning from them, and growing - personally, professionally and socially.
This graduate capability is supported by:
Our graduates will take with them the intellectual development, depth and breadth of knowledge, scholarly understanding, and specific subject content in their chosen fields to make them competent and confident in their subject or profession. They will be able to demonstrate, where relevant, professional technical competence and meet professional standards. They will be able to articulate the structure of knowledge of their discipline, be able to adapt discipline-specific knowledge to novel situations, and be able to contribute from their discipline to inter-disciplinary solutions to problems.
This graduate capability is supported by:
We want our graduates to be capable of reasoning, questioning and analysing, and to integrate and synthesise learning and knowledge from a range of sources and environments; to be able to critique constraints, assumptions and limitations; to be able to think independently and systemically in relation to scholarly activity, in the workplace, and in the world. We want them to have a level of scientific and information technology literacy.
This graduate capability is supported by:
Our graduates should be capable of researching; of analysing, and interpreting and assessing data and information in various forms; of drawing connections across fields of knowledge; and they should be able to relate their knowledge to complex situations at work or in the world, in order to diagnose and solve problems. We want them to have the confidence to take the initiative in doing so, within an awareness of their own limitations.
This graduate capability is supported by:
We want to develop in our students the ability to communicate and convey their views in forms effective with different audiences. We want our graduates to take with them the capability to read, listen, question, gather and evaluate information resources in a variety of formats, assess, write clearly, speak effectively, and to use visual communication and communication technologies as appropriate.
This graduate capability is supported by:
As local citizens our graduates will be aware of indigenous perspectives and of the nation's historical context. They will be engaged with the challenges of contemporary society and with knowledge and ideas. We want our graduates to have respect for diversity, to be open-minded, sensitive to others and inclusive, and to be open to other cultures and perspectives: they should have a level of cultural literacy. Our graduates should be aware of disadvantage and social justice, and be willing to participate to help create a wiser and better society.
This graduate capability is supported by:
We want our graduates to be aware of and have respect for self and others; to be able to work with others as a leader and a team player; to have a sense of connectedness with others and country; and to have a sense of mutual obligation. Our graduates should be informed and active participants in moving society towards sustainability.
This graduate capability is supported by:
The unit is being run similarly to 2017, but there are some variations in the topics due to Prof Peter Karuso being away. Lectures will be presented by A/Prof Joanne Jamie and Dr Andrew Piggott (new to this unit). The most significant changes in assessment is the laboratoty group report being submitted in stages, for assessment of some aspects earlier in the session to ease the load towards the end of the semester.
Joanne Jamie and Peter Karuso are the main taching staff in this unit. There are no formal office hours for the teaching staff, however, you are expected to contact them on any questions you have with their topics and the unit convenor (Joanne Jamie) on any administrative questions as soon as your concern arises. You are encouraged to phone or email to organise a meeting. You may also wish to ask questions using the discussion board on the website.