Unit convenor and teaching staff |
Unit convenor and teaching staff
Unit Convenor
Phani Rekha Potluri
Contact via By email
E8A 306
Tuesday 11am-12pm
Coordinator
Bridget Mabbutt
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Credit points |
Credit points
4
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Prerequisites |
Prerequisites
Admission to MBiotech or MBiotechMCom or MLabQAMgt or MRadiopharmSc or MSc or MBioBus or GradCertLabQAMgt or GradDipLabQAMgt
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Corequisites |
Corequisites
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Co-badged status |
Co-badged status
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Unit description |
Unit description
This unit outlines molecular principles underlying today's developments in protein science and biomedical research. As well as detailing modern separation technologies, the course addresses structural biology, protein analysis and bioinformatics. Practices common in the biotechnology and pharmaceutical industries to isolate recombinant proteins are emphasized. Analysis methods are introduced in relation to proteomics, genomics and biochemical research. Molecular properties leading to the 3D shape of proteins are detailed, and contemporary structure methods outlined.
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Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates
On successful completion of this unit, you will be able to:
Three modes of assessment are used to determine your progress in CBMS832.
Name | Weighting | Hurdle | Due |
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“Pet Protein” project report | 15% | No | April 13 |
Protein workshop report | 15% | No | April 30 |
Molecular graphics practical | 10% | No | May 25 |
"Pet Protein" seminar, model | 20% | No | June 8 |
Final examination | 40% | No | University Examination period |
Due: April 13
Weighting: 15%
Due: April 30
Weighting: 15%
Due: May 25
Weighting: 10%
Due: June 8
Weighting: 20%
This is a continuation of the pet protein case study
Pet Protein B: Structure, model, seminar & questions: due June 8, model - 10% and presentation - 10%
Due: University Examination period
Weighting: 40%
Classes:
Laboratory Sessions:
A block chromatography workshop (workshop_1 to workshop_5) is scheduled in the first week of mid-semester break, i.e. from April 16-20.
CBMS 832 students are required to attend ONLY Workshop 3 and Workshop 4 and 5 scheduled for Apr 18 (Wednesday) from 9am-11am and Apr 19-20, (Thurs-Fri) from 9am-5pm.
Required and Recommended texts
Web resources
The Unit will run as an online unit within iLearn (http://learn.mq.edu.au). Within this Unit, you will be introduced to Web-based tools, search engines and graphics software that are commonly used today in protein science. There are many excellent websites, apps and YouTube presentations to show how protein are made and constantly move around.
It is an expectation that you will become familiar with the following sites during the course:
Technology Requirements
Lectures
1 - 3 |
FUNCTIONAL GROUPS IN PROTEINS |
4 |
ISOLATING BIOMOLECULES recombinant sources; quantitation & detection |
5 & 6 |
SEPARATION OF PROTEIN MIXTURES separation by precipitation; gel filtration for separation |
7 - 10 |
CHROMATOGRAPHY FOR PURIFICATION ion exchange; hydrophobic/reversed-phase; affinity chromatography |
11 -13 |
PROTEIN ANALYSIS METHODS 2D gel electrophoresis; mass spectrometry; sugar/glycoprotein analysis |
14 - 16 |
PROTEIN FOLDS AND DOMAINS all alpha-structures (globin fold, helix bundles); all beta structures (antiparallel barrels, the beta helix); mixed alpha/beta folds |
17- 19 |
TERTIARY STRUCTURE DETERMINATION x-ray crystallography; NMR spectroscopy |
20-22 |
HOW PROTEINS FOLD IN SOLUTION circular dichroism;thermodynamics of protein folds; invivo folding |
23-24 |
BIOINFORMATICS structure prediction methods; the CASP project |
25 |
MEMBRANE PROTEINS |
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