Unit convenor and teaching staff |
Unit convenor and teaching staff
Lecturer
Joanne Jamie
Contact via 98508283
4 Wally's Walk (F7B) room 231
Have an open door policy, but students are encouraged to arrange a meeting via email.
Lecturer in charge
Peter Karuso
Contact via 9850 8290
F7B232
Wednesday 6-8 PM
Tutor and administrator
Vaughan Moon
Contact via 9850 8309
4 Wally's Walk (F7B) room 204
Wednesday 6-8 PM
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Credit points |
Credit points
4
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Prerequisites |
Prerequisites
(Admission to MBiotech or MBioBus or MLabQAMgt or MRadiopharmSc or MSc or GradCertLabQAMgt or GradDipLabQAMgt) and permission by special approval
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Corequisites |
Corequisites
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Co-badged status |
Co-badged status
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Unit description |
Unit description
This unit builds on the fundamentals of medicinal chemistry, including the discovery, design and development of new medicines. The aim of the unit is to integrate chemical biology and organic chemistry to reveal how these are used in medicinal chemistry to design and synthesise new drugs and to understand their mode of action. The unique aspect of this unit is the focus on computational chemistry in the field of drug design and development. This includes aspects of molecular modelling, molecular dynamics, docking, pharmacophore modelling and QSAR as they relate to the understanding of drug action and design of new drugs.
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Information about important academic dates including deadlines for withdrawing from units are available at https://www.mq.edu.au/study/calendar-of-dates
On successful completion of this unit, you will be able to:
On line quizzes are multiple choice questions on the previous 2 weeks work.
The report and presentation is a major work that you will start preparing in week 5 and complete in week 13. It involves a written report and a powerpoint presentation (15 minutes)
The final exam is a 3 hr written exam
The weekly classes are a participation hurdle and failure to participate in at least 10 of the 13 weekly classes will result in you failing CBMS842. If you are unable to attend a class, please contact Peter Karuso (peter.karuso@mq.edu.au) immediately. In addition, you must submit a Special Consideration request at ask.mq.edu.au to justify your absence.
Your marks (in-class and online quizzes, report and presentation) will be placed on the CBMS842 web site.
Your final grade will be based on the mark from the aggregation of the individual assessments, with 50% or greater needed overall for a pass.
Medical certificates or official documents must be lodged as part of a disruption to studies request at ask.mq.edu.au as soon as possible if you are absent for any of the weekly classes, assessment tasks or miss the due date for any of the on-line tasks. If your reason is regarded as valid for missing the in-class quizzes, you will be given an average of the other quizzes done; with the on-line quizzes an extension of time will be provided if the disruption to studies request is approved. If you miss the final exam for a valid reason, a supplementary exam will be provided. Any assessment tasks not submitted on time that does not get approval through the disruption to studies request will get a 10% deduction of marks for every weekday late.
Final Examination Details: The examination timetable will be available in Draft form approximately eight weeks before the commencement of the examinations and in final form approximately four weeks before the commencement of the examinations. You are expected to present yourself for examination at the time and place designated by the University in the Examination Timetable. This could be any day after the final week of semester and up until the final day of the official examination period. It is Macquarie University policy to not set early examinations for individuals or groups of students. All students are expected to ensure that they are available until the end of the teaching semester, that is, the final day of the official examination period. NOTE: If you apply for a supplementary examination, you must make yourself available for the week of Dec 4-8. If you are not available at that time, there is no guarantee an additional examination time will be offered. Specific examination dates and times will be determined at a later date.
The only exception to sitting an examination at the designated time is because of documented illness or unavoidable disruption. Absence from the final exam will result in a grade of F except in the case of a genuine medical emergency or misadventure as defined by the University (see below). In these circumstances you should apply for a Supplementary Exam at ask.mq.edu.au.
Name | Weighting | Hurdle | Due |
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Five on-line assessments | 25% | No | Weeks 3, 5, 7, 9, 11 |
Final Exam | 50% | No | Week 15 |
Research presentation | 25% | No | Week 13 |
Class participation | 0% | Yes | weeks 1-13 |
Due: Weeks 3, 5, 7, 9, 11
Weighting: 25%
5 on-line quizzes, worth 5% each
Due: Week 15
Weighting: 50%
This is a 3 hr final exam
Due: Week 13
Weighting: 25%
Using what you have learnt, pick a drug target, research what is known about this target and summarise the relevant literature and design your own library of compounds to test. Present this review and design task to the rest of the class in week 13 and hand in a written report.
Due: weeks 1-13
Weighting: 0%
This is a hurdle assessment task (see assessment policy for more information on hurdle assessment tasks)
Participation in the weekly classes is a hurdle and you are expected to attend all classes. In the event of illness or misadventure, you can justify your absence from a class by submitting a special consideration request.
This is a self taught unit using the "molecular conceptor" and MOE software. Each week a set number of tasks are assigned and assessed. There is no text book set for this unit but the material in the CBMS606 text book (Patrick, "Medicinal Chemistry", 5th Ed) is assumed knowledge.
WEEK 1 – Introduction to drug design
Introduction to Drug Discovery
Principles of Rational Drug Design
WEEK 2 – Molecular basis of drugs
Molecular Geometry
Molecular Energies
Molecular Graphics
WEEK 3 – Library design
Library Design
Case Studies in Library Design
WEEK 4 - Structural bioinformatics and protein structure
Protein Structure
Structual Bioinformatics
WEEK 5 – Structure-activity relationships (SAR)
Structure Activity Relationships (SAR)
WEEK 6 – SAR case studies
Case Studies in SAR Analyses
Case Studies in Advanced Analog Design
WEEK 7 – Molecular docking
Molecular Docking: Principles and Methods
WEEK 8 – Structure based design
Introduction to Protein-Ligand Binding
Principles of Structure-Based Design
WEEK 9 – Structure based design & case studies
Case Studies in Structure-Based Design
Case Studies of Docking in Drug Discovery
Analyses of Protein-Ligand Complexes
WEEK 10 – Ligand based design A
Principles in Pharmacophore Elucidation
Ligand-Based Approaches
WEEK 11 – Ligand based design B & case studies
Ligand-Based Approaches
Examples of Pharmacophores
Case Studies in Ligand-Based Design
WEEK 12 – QSAR (optional)
QSAR: Principles and Methods
Case Studies in QSAR and 3d-QSAR
MOE WORKSHOPS
Macquarie University policies and procedures are accessible from Policy Central (https://staff.mq.edu.au/work/strategy-planning-and-governance/university-policies-and-procedures/policy-central). Students should be aware of the following policies in particular with regard to Learning and Teaching:
Undergraduate students seeking more policy resources can visit the Student Policy Gateway (https://students.mq.edu.au/support/study/student-policy-gateway). It is your one-stop-shop for the key policies you need to know about throughout your undergraduate student journey.
If you would like to see all the policies relevant to Learning and Teaching visit Policy Central (https://staff.mq.edu.au/work/strategy-planning-and-governance/university-policies-and-procedures/policy-central).
Macquarie University students have a responsibility to be familiar with the Student Code of Conduct: https://students.mq.edu.au/study/getting-started/student-conduct
Results shown in iLearn, or released directly by your Unit Convenor, are not confirmed as they are subject to final approval by the University. Once approved, final results will be sent to your student email address and will be made available in eStudent. For more information visit ask.mq.edu.au.
Macquarie University provides a range of support services for students. For details, visit http://students.mq.edu.au/support/
Learning Skills (mq.edu.au/learningskills) provides academic writing resources and study strategies to improve your marks and take control of your study.
Students with a disability are encouraged to contact the Disability Service who can provide appropriate help with any issues that arise during their studies.
For all student enquiries, visit Student Connect at ask.mq.edu.au
For help with University computer systems and technology, visit http://www.mq.edu.au/about_us/offices_and_units/information_technology/help/.
When using the University's IT, you must adhere to the Acceptable Use of IT Resources Policy. The policy applies to all who connect to the MQ network including students.
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There are no major changes since last time.